Towards regenerative therapy for cardiac disease

Leon M Ptaszek; Moussa Mansour; Jeremy N Ruskin; Kenneth R Chien

doi:10.1016/S0140-6736(12)60075-0

Towards regenerative therapy for cardiac disease

Lancet. 2012 Mar 10;379(9819):933-942. doi: 10.1016/S0140-6736(12)60075-0.

Authors

Leon M Ptaszek¹, Moussa Mansour², Jeremy N Ruskin², Kenneth R Chien³

Affiliations

¹ Cardiac Arrhythmia Service, Massachusetts General Hospital Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
² Cardiac Arrhythmia Service, Massachusetts General Hospital Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
³ Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Electronic address: kchien@harvard.edu.

PMID: 22405796
DOI: 10.1016/S0140-6736(12)60075-0

Abstract

Development of regenerative therapeutic strategies to reverse the progression of advanced heart failure is one of the most urgent clinical needs of this century. Insights gained from clinical trials of adult stem cells, together with fundamental scientific advances in cardiac stem cell and regenerative biology, are beginning to yield potential new targets and strategies for regenerative therapies. Of particular importance are new scientific discoveries related to intrinsic cardiac regeneration, renewal factors that can trigger regeneration, and tissue-engineering technology, which are beginning to change the way investigators view the scientific and clinical position of cardiovascular regenerative therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Heart / physiology*
Heart Failure / therapy*
Humans
Myocytes, Cardiac / transplantation
Pluripotent Stem Cells / transplantation
Regeneration / physiology*
Stem Cell Transplantation* / methods
Tissue Engineering / methods
Transplantation, Autologous

Grants and funding

U01 HL100408/HL/NHLBI NIH HHS/United States