Renal cancer: oxygen meets metabolism

Exp Cell Res. 2012 May 15;318(9):1057-67. doi: 10.1016/j.yexcr.2012.02.026. Epub 2012 Mar 3.

Abstract

Over the last two decades molecular studies of inherited tumor syndromes that are associated with the development of kidney cancer have led to the identification of genes and biochemical pathways, which play key roles in the malignant transformation of renal epithelial cells. Some of these findings have broad biological impact and extend beyond renal cancer. This review's focus is on the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) oxygen-sensing pathway and its role in physiology, energy metabolism and tumorigenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Carcinoma, Renal Cell / metabolism*
  • Humans
  • Kidney Neoplasms / metabolism*
  • Models, Biological
  • Oxygen / metabolism*
  • Von Hippel-Lindau Tumor Suppressor Protein / metabolism

Substances

  • Von Hippel-Lindau Tumor Suppressor Protein
  • Oxygen