Hormonal therapy in breast cancer: a model disease for the personalization of cancer care

Mol Oncol. 2012 Apr;6(2):222-36. doi: 10.1016/j.molonc.2012.02.003. Epub 2012 Feb 24.


The treatment of breast cancer is driven by subtype classification, of which the assessment of hormone receptor status is one of the important determinants of therapy. The use of hormonal therapy to treat estrogen-receptor positive breast cancer has been studied for over a century and is one of the well-described uses of personalized medicine. In this review, we will describe the classification of hormone receptor status and the various endocrine treatment strategies. Opportunities for personalization of care are illustrated.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Female
  • Humans
  • Precision Medicine*
  • Premenopause
  • Receptors, Estrogen / metabolism


  • Antineoplastic Agents, Hormonal
  • Receptors, Estrogen