Lycopene in the management of oral lichen planus: a placebo-controlled study

Indian J Dent Res. 2011 Sep-Oct;22(5):639-43. doi: 10.4103/0970-9290.93448.


Context: Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported.

Aim: This study was designed to assess the efficacy of systemic lycopene in the management of OLP.

Settings and design: This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India.

Materials and methods: Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer's Exact test.

Results: A higher (84%) reduction in burning sensation was seen in lycopene than in the placebo group (67%). All 15 (100%) patients in the lycopene group showed 50% or more benefit and 11 (73.3%) patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%), respectively, in the placebo group.

Conclusion: Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use*
  • Carotenoids / administration & dosage
  • Carotenoids / therapeutic use*
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Lichen Planus, Oral / drug therapy*
  • Lycopene
  • Male
  • Middle Aged
  • Oxidative Stress / drug effects
  • Pain Measurement
  • Placebos
  • Prospective Studies
  • Remission Induction
  • Treatment Outcome
  • Young Adult


  • Antioxidants
  • Placebos
  • Carotenoids
  • Lycopene