Long-term radiographic outcome of nodular bronchiectatic Mycobacterium avium complex pulmonary disease

Int J Tuberc Lung Dis. 2012 May;16(5):660-4. doi: 10.5588/ijtld.11.0534. Epub 2012 Mar 7.


Background: Although Mycobacterium avium complex pulmonary disease (MAC-PD) is a growing health problem, little is known about long-term radiographic outcome and factors for deterioration in patients with MAC-PD.

Methods: Data on patients with nodular bronchiectatic (NBE) MAC-PD who underwent regular follow-up for >5 years were retrospectively reviewed. Changes in plain chest radiograph (CXR) and baseline characteristics were compared between the stable and deteriorated groups.

Results: Seventy-two patients were investigated, including 30 patients who were examined 10 years after the initial visit. One patient (1.4%) showed progressive or remarkably progressive disease on CXR at 1 year; this rate increased to 22.2% at 5 years and to 53.3% at 10 years. Body mass index (BMI) at the initial visit was lower in the deteriorated group than in the stable group. Cavitary disease and resistance to a macrolide were seen more frequently at the initial visit in the deteriorated group than in the stable group.

Conclusions: NBE MAC-PD is a slowly but substantially progressive long-term infection (5-10 years). Our data suggest that patients with lower BMI, cavitary disease and resistance to a macrolide at initial visit are more likely to progress to deteriorating disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use*
  • Body Mass Index
  • Bronchiectasis / diagnostic imaging*
  • Cohort Studies
  • Disease Progression
  • Drug Resistance, Bacterial
  • Female
  • Follow-Up Studies
  • Humans
  • Macrolides / therapeutic use
  • Male
  • Middle Aged
  • Mycobacterium avium Complex / drug effects
  • Mycobacterium avium Complex / isolation & purification*
  • Mycobacterium avium-intracellulare Infection / diagnostic imaging*
  • Mycobacterium avium-intracellulare Infection / drug therapy
  • Mycobacterium avium-intracellulare Infection / microbiology
  • Radiography
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Macrolides