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. 2012 May;16(5):656-9.
doi: 10.5588/ijtld.11.0707. Epub 2012 Mar 8.

Interleukin-10 and Interferon-Gamma Patterns During Tuberculosis Treatment: Possible Association With Recurrence

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Free PMC article

Interleukin-10 and Interferon-Gamma Patterns During Tuberculosis Treatment: Possible Association With Recurrence

P M Lago et al. Int J Tuberc Lung Dis. .
Free PMC article

Abstract

Interleukin (IL) 10 and interferon-gamma (IFN-) levels in induced sputum supernatants of 21 tuberculosis (TB) patients at diagnosis and during chemotherapy were correlated to recurrence rates. IL-10 decreased until day 60 of treatment (T60), and between T60 and T180 it increased again in 7 cases (Pattern 1) and further decreased in 14 cases (Pattern 2). Follow-up of 69 months was performed in 20/21 cases; 6 had recurrence of TB, of which 5/7 (71%) had Pattern 1 and 1/13 (7.7%) Pattern 2 (OR 30.0, 95%CI 2.19411.3, P 0.0072). This was not observed for IFN-. High IL-10 levels at the end of treatment may function as a risk factor for TB recurrence.

Figures

Figure
Figure
Patterns 1 and 2 of IL-10 and IFN-γ levels in the sputum of TB patients at the moment of diagnosis (T0) and during treatment. (Student’s t-test for paired samples, significance 95%. ELISA sensitivity for IL-10 = 5 pg/ml and for IFN-γ = 0.08 UI/ml.) In Pattern 1, the IL-10 levels had decreased at T60 and had increased again by the end of treatment (T180; A), whereas in Pattern 2, the IL-10 levels had decreased at T60 and had decreased further at the end of treatment (T180; B). Similar patterns were observed in the IFN-γ levels (C and D). C shows Pattern 1 with increased IFN-γ levels between T60 and T180 (T60 = 0.1348 ± 0.039 UI/ml; n = 9; T180 = 0.776 ± 0.233 UI/ml; n = 9; P = 0.0067). IFN-γ levels at diagnosis (T0) were similar to those at the end of treatment (T0 = 0.666 ± 0.38 UI/ml, n = 9; T180 = 0.776 ± 0.233 UI/ml; n = 9; P = NS). The remaining 11 were Pattern 2 cases showing a consistent drop in IFN-γ at all time points, including T180 (T0 = 0.92 ± 0.394 UI/ml; n = 11; T180 = 0.261 ± 0.124 UI/ml; n = 11, P = 0.0426; D). In the case of IL-10, Pattern 1 was associated with increased TB recurrence rates. For IFN-γ, the 6 recurrent cases were distributed equally between Patterns 1 and 2. IL = interleukin; IFN-γ = interferon-gamma; TB = tuberculosis.

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