Comparison of clonidine and midazolam as anxiolytic premedication before wisdom tooth surgery: a randomized, double-blind, crossover pilot study

Oral Maxillofac Surg. 2012 Dec;16(4):341-7. doi: 10.1007/s10006-012-0319-8. Epub 2012 Mar 13.

Abstract

Purpose: Anxiolytic and possible side effects of clonidine 150 μg compared to midazolam 7.5 mg for premedication in surgical wisdom tooth extraction were evaluated.

Methods: In a prospective, randomized, double-blind crossover trial, ten patients undergoing bilateral wisdom tooth surgery received clonidine or midazolam orally 1 h before the treatment. Patients receiving midazolam for the first surgery received clonidine at the second surgery and vice versa. The anxiolytic efficacy was evaluated with a visual analogue scale (VAS) upon admission and 30, 50 and 60 min after administration of the medication. Patient satisfaction was recorded on a VAS after surgery and 7 days postoperatively.

Results: As soon as 30 min after administration of midazolam (p < 0.03) and clonidine (p < 0.02), an anxiolytic effect was recorded. Both medications did not differ in patient satisfaction.

Conclusion: Oral administration of clonidine 150 μg and midazolam 7.5 mg were rated as medications with equal anxiolytic effects before wisdom tooth surgery under local anesthesia.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / adverse effects
  • Anti-Anxiety Agents / therapeutic use*
  • Blood Pressure / drug effects
  • Clonidine / administration & dosage
  • Clonidine / adverse effects
  • Clonidine / therapeutic use*
  • Cross-Over Studies
  • Dental Anxiety / classification
  • Dental Anxiety / prevention & control
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Heart Rate / drug effects
  • Humans
  • Male
  • Midazolam / administration & dosage
  • Midazolam / adverse effects
  • Midazolam / therapeutic use*
  • Molar, Third / surgery*
  • Patient Satisfaction
  • Pilot Projects
  • Premedication*
  • Prospective Studies
  • Time Factors
  • Tooth Extraction* / methods
  • Treatment Outcome
  • Young Adult

Substances

  • Anti-Anxiety Agents
  • Clonidine
  • Midazolam