Spontaneous coronary artery dissection during cabergoline therapy

Tex Heart Inst J. 2012;39(1):92-4.

Abstract

Although spontaneous coronary artery dissection is a rare cause of acute coronary syndrome, it should be considered during the evaluation of patients who have chest pain. Coronary vasospasm can lead to spontaneous dissection. The dopamine agonist cabergoline is known to cause digital vasospasm. Herein, we report a case of spontaneous right coronary artery dissection in a 43-year-old woman who was taking cabergoline as therapy for prolactinoma. To our knowledge, this is the first report of an apparent relationship between cabergoline therapy and spontaneous coronary artery dissection. The possible association of cabergoline with coronary artery spasm and dissection should be considered in patients who present with chest pain while taking this medication.

Keywords: Acute coronary syndrome/diagnosis/etiology/therapy; cabergoline/adverse effects; coronary vasospasm/chemically induced; dopamine agonists/adverse effects; rupture, spontaneous/diagnosis/etiology; substance-related disorders/complications.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angina Pectoris / chemically induced
  • Antineoplastic Agents, Hormonal / adverse effects*
  • Aortic Dissection / chemically induced*
  • Aortic Dissection / diagnostic imaging
  • Aortic Dissection / drug therapy
  • Aortic Dissection / physiopathology
  • Cabergoline
  • Cardiovascular Agents / therapeutic use
  • Coronary Aneurysm / chemically induced*
  • Coronary Aneurysm / diagnostic imaging
  • Coronary Aneurysm / drug therapy
  • Coronary Aneurysm / physiopathology
  • Coronary Angiography
  • Coronary Vasospasm / chemically induced*
  • Coronary Vasospasm / diagnostic imaging
  • Coronary Vasospasm / drug therapy
  • Coronary Vasospasm / physiopathology
  • Ergolines / adverse effects*
  • Female
  • Humans
  • Pituitary Neoplasms / drug therapy*
  • Predictive Value of Tests
  • Prolactinoma / drug therapy*
  • Recurrence
  • Risk Factors
  • Time Factors
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Hormonal
  • Cardiovascular Agents
  • Ergolines
  • Cabergoline