Myocardial perfusion single-photon emission tomography (SPET) and positron emission tomography-computed tomography (PET-CT) imaging for congenitally corrected transposition of great arteries

Pediatr Cardiol. 2012 Dec;33(8):1435-9. doi: 10.1007/s00246-012-0261-4. Epub 2012 Mar 14.


Congenitally corrected transposition of great arteries (ccTGA) consists of both atrioventricular and ventriculo-arterial discordance. In patients with ccTGA, the pulmonary artery arises from the left ventricle, whereas the aorta arises from the right ventricle. The burden of the systemic blood pressure on the right ventricle involves an increased risk of coronary artery disease (CAD) and, as a long-term consequence, myocardial hypertrophy and gradual failure. This report describes the case of an adult patient affected by ccTGA who was referred for an episode of atypical chest pain while at rest. First-line diagnostic examinations were inconclusive. Myocardial perfusion single-photon emission tomography (SPET) was performed to exclude CAD, but the congenital abnormalities of the patient's heart made interpretation of the images particularly difficult. A perfusion positron emission tomography-computed tomography (PET-CT) scan with (13)N-ammonia then was suggested, which unmasked an unexpected artifact. The case report demonstrates that hybrid imaging techniques such as SPET-CT and PET-CT should be used systematically when CAD is suspected for patients with abnormal anatomy of the heart, including ccTGA.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Congenitally Corrected Transposition of the Great Arteries
  • Electrocardiography
  • Humans
  • Male
  • Multimodal Imaging*
  • Positron-Emission Tomography*
  • Tomography, Emission-Computed, Single-Photon*
  • Tomography, X-Ray Computed*
  • Transposition of Great Vessels / diagnostic imaging*

Supplementary concepts

  • Congenitally corrected transposition of the great arteries