Interleukin-8, a promising predictor for prognosis of pancreatic cancer

World J Gastroenterol. 2012 Mar 14;18(10):1123-9. doi: 10.3748/wjg.v18.i10.1123.


Aim: To investigate the value of interleukin-8 (IL-8), a pro-inflammatory chemokine, in predicting the prognosis of pancreatic cancer.

Methods: Expression of IL-8 and its receptor CXCR1 was assessed by immunohistochemistry in pancreatic cancer and chronic pancreatitis samples. Enzyme-linked immunosorbent assay was used to detect the serum IL-8 levels in pancreatic cancer patients. Human pancreatic cancer tissues were heterotopically transplanted to the immune-deficiency mice to evaluate the effect of serum IL-8 on the tumorigenesis of the cancer samples.

Results: IL-8 and CXCR1 proteins were both over-expressed in pancreatic adenocarcinoma samples (55.6% and 65.4%, respectively) compared with the matched para-cancer tissues (25.9% and 12.3%, P < 0.01), or chronic pancreatitis (0% and 25%, P < 0.05). Serum IL-8 levels in pancreatic cancer patients (271.1 ± 187.7 ng/mL) were higher than in other digestive system tumors, such as gastric cancer (41.77 ± 9.11 ng/mL, P = 0.025), colorectal carcinoma (78.72 ± 80.60 ng/mL, P = 0.032) and hepatocellular carcinoma (59.60 ± 19.80 ng/mL, P = 0.016). In vivo tumorigenesis analysis further proved that tumor tissues from patients with higher serum IL-8 levels grew faster than those with lower IL-8 levels.

Conclusion: IL-8 can be a fine serum marker for predicting the prognosis pancreatic cancer.

Keywords: CXCR1; Enzyme-linked immunosorbent assay; Immunohistochemistry; Interleukin-8; Pancreatic cancer; Tumor implantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Biomarkers, Tumor / blood*
  • Child
  • Female
  • Humans
  • Interleukin-8 / blood*
  • Male
  • Mice
  • Mice, Nude
  • Mice, SCID
  • Middle Aged
  • Neoplasm Transplantation
  • Pancreatic Neoplasms / blood*
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / pathology
  • Prognosis
  • Receptors, Interleukin-8A / metabolism
  • Young Adult


  • Biomarkers, Tumor
  • Interleukin-8
  • Receptors, Interleukin-8A