Objective: To report in vitro susceptibilities of penicillin-susceptible and penicillin-intermediate Streptococcus pneumoniae isolates to cephalosporins, vancomycin and teicoplanin.
Design: Minimal inhibitory concentrations (mic) were determined according to National Committee for Clinical Laboratory Standards guidelines for 17 penicillin-susceptible isolates (mic 0.06 mg/L or less) and 16 isolates showing intermediate susceptibility to penicillin (mic 0.12 to 1.0 mg/L).
Setting: Tertiary care university centre.
Main results: Comparison of the mic(90) values with those of other antibiotics tested demonstrated that ceftriaxone, cefotaxime and teicoplanin were the most active agents against penicillin-susceptible strains. However, teicoplanin had the lowest mic and was superior to other agents against strains with intermediate penicillin susceptibility. The mics of all cephalosporins increased in concordance with the mic of penicillin.
Conclusion: Isolates demonstrating intermediate susceptibility or resistance to penicillin should be routinely evaluated for susceptibility to clinically important cephalosporins.
Objectifs:: Étudier la sensibilité in vitro d’isolats de Streptococcus pneumoniae sensibles à la pénicilline et modérément résistants à la pénicilline, à l’égard des céphalosporines, de la vancomycine et de la téicoplanine.
Modèle::
Les concentrations minimales in vitro (
Contexte:: Centre hospitalier de soins tertiaires.
Principaux Résultats::
La comparaison des valeurs de
Conclusion:: Les isolats qui manifestent une sensibilité intermédiaire ou une résistance à la pénicilline doivent être évalués d’office à l’égard de la susceptibilité aux céphalosporines d’usage courant.
Keywords: Cephalosporins; Resistance; Streptococcuspneumoniae.