Lower serum interleukin-2 levels in schizophrenic patients with tardive dyskinesia

Psychiatry Res. 2012 Jul 30;198(2):329-31. doi: 10.1016/j.psychres.2012.01.002. Epub 2012 Mar 13.


We determined serum interleukin-2 (IL-2) levels between schizophrenic patients with (n=45) and without tardive dyskinesia (TD; n=45) compared to normal controls (n=50). TD patients had lower serum IL-2 levels than non-TD patients, but higher IL-2 levels than normal controls. IL-2 was associated with the negative symptoms of schizophrenia, but not with TD severity. Immune disturbance may be involved in the pathophysiology of TD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Case-Control Studies
  • Female
  • Humans
  • Interleukin-2 / metabolism*
  • Male
  • Middle Aged
  • Movement Disorders / blood*
  • Movement Disorders / complications
  • Movement Disorders / diagnosis
  • Schizophrenia / blood*
  • Schizophrenia / complications
  • Schizophrenia / diagnosis
  • Severity of Illness Index


  • Interleukin-2