Abstract
Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2'-nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13'-bromo-tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / pharmacology
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Antitubercular Agents* / chemistry
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Antitubercular Agents* / pharmacology
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Benzylisoquinolines* / chemistry
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Benzylisoquinolines* / pharmacology
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Drug Resistance, Multiple, Bacterial / drug effects*
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Humans
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Magnetic Resonance Spectroscopy
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Menispermaceae / chemistry*
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium tuberculosis / drug effects*
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Plant Extracts / pharmacology
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Plant Roots / chemistry
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Tuberculosis, Multidrug-Resistant / drug therapy
Substances
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Alkaloids
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Antitubercular Agents
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Benzylisoquinolines
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Plant Extracts
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tiliacorinine