Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2902-5. doi: 10.1016/j.bmcl.2012.02.053. Epub 2012 Feb 23.

Abstract

Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2'-nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13'-bromo-tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / pharmacology
  • Antitubercular Agents* / chemistry
  • Antitubercular Agents* / pharmacology
  • Benzylisoquinolines* / chemistry
  • Benzylisoquinolines* / pharmacology
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Menispermaceae / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects*
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Tuberculosis, Multidrug-Resistant / drug therapy

Substances

  • Alkaloids
  • Antitubercular Agents
  • Benzylisoquinolines
  • Plant Extracts
  • tiliacorinine