The Immune Contexture in Human Tumours: Impact on Clinical Outcome

Nat Rev Cancer. 2012 Mar 15;12(4):298-306. doi: 10.1038/nrc3245.

Abstract

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokines / metabolism
  • Cytokines / metabolism
  • Disease-Free Survival
  • Humans
  • Mice
  • Molecular Targeted Therapy
  • Neoplasms / drug therapy
  • Neoplasms / immunology*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Prognosis
  • Tumor Microenvironment
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Chemokines
  • Cytokines
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A