A systematic review of hip fracture incidence and probability of fracture worldwide
- PMID: 22419370
- PMCID: PMC3421108
- DOI: 10.1007/s00198-012-1964-3
A systematic review of hip fracture incidence and probability of fracture worldwide
Abstract
The country-specific risk of hip fracture and the 10-year probability of a major osteoporotic fracture were determined on a worldwide basis from a systematic review of literature. There was a greater than 10-fold variation in hip fracture risk and fracture probability between countries.
Introduction: The present study aimed to update the available information base available on the heterogeneity in the risk of hip fracture on a worldwide basis. An additional aim was to document variations in major fracture probability as determined from the available FRAX models.
Methods: Studies on hip fracture risk were identified from 1950 to November 2011 by a Medline OVID search. Evaluable studies in each country were reviewed for quality and representativeness and a study (studies) chosen to represent that country. Age-specific incidence rates were age-standardised to the world population in 2010 in men, women and both sexes combined. The 10-year probability of a major osteoporotic fracture for a specific clinical scenario was computed in those countries for which a FRAX model was available.
Results: Following quality evaluation, age-standardised rates of hip fracture were available for 63 countries and 45 FRAX models available in 40 countries to determine fracture probability. There was a greater than 10-fold variation in hip fracture risk and fracture probability between countries.
Conclusions: Worldwide, there are marked variations in hip fracture rates and in the 10-year probability of major osteoporotic fractures. The variation is sufficiently large that these cannot be explained by the often multiple sources of error in the ascertainment of cases or the catchment population. Understanding the reasons for this heterogeneity may lead to global strategies for the prevention of fractures.
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Comment in
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Variations in solar UVB doses and serum 25-hydroxyvitamin D concentrations may explain the worldwide variation in hip fracture incidence.Osteoporos Int. 2012 Sep;23(9):2399-400; author reply 2401-2. doi: 10.1007/s00198-012-2026-6. Epub 2012 Jun 21. Osteoporos Int. 2012. PMID: 22717914 No abstract available.
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