Chronic kidney disease and the risk of stent thrombosis after percutaneous coronary intervention with drug-eluting stents

Catheter Cardiovasc Interv. 2012 Sep 1;80(3):361-7. doi: 10.1002/ccd.23464. Epub 2012 Mar 14.


Background: Chronic kidney disease (CKD) has been demonstrated to be associated with adverse clinical outcomes for patients with coronary artery disease (CAD). However, data on relation of CKD and stent thrombosis (ST) after drug-eluting stent (DES) implantation are limited.

Objectives: This study was designed to examine whether CKD is associated with higher incidence of ST after elective coronary DES implantation compared with patients with normal renal function.

Methods: We consecutively enrolled 2,862 patients undergoing elective percutaneous coronary intervention (PCI) with DES. Demographic and clinical data were collected preoperatively. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min, calculated using the modified MDRD equation. The primary outcome was 1-year definite or probable ST.

Results: Four hundred and forty-five participants (15.5%) had CKD before procedure. The incidence of 1-year definite or probable ST was significantly higher in CKD patients compared with patients with normal renal function (1.8% vs. 0.6%, P = 0.014). After adjustment for multiple clinical and biochemical covariates, CKD was an independent predictor of 1-year definite or probable ST (hazard rate [HR] 0.396, 95% CI 0.165-0.951, P = 0.038).

Conclusion: CKD is significantly associated with increased incidence of 1-year definite or probable ST in patients undergoing PCI with DES.

MeSH terms

  • Aged
  • Chi-Square Distribution
  • China / epidemiology
  • Coronary Artery Disease / epidemiology
  • Coronary Artery Disease / therapy*
  • Coronary Thrombosis / epidemiology*
  • Coronary Thrombosis / mortality
  • Drug-Eluting Stents*
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Incidence
  • Kaplan-Meier Estimate
  • Kidney / physiopathology
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Percutaneous Coronary Intervention / adverse effects*
  • Percutaneous Coronary Intervention / instrumentation*
  • Percutaneous Coronary Intervention / mortality
  • Proportional Hazards Models
  • Prospective Studies
  • Prosthesis Design
  • Renal Insufficiency, Chronic / diagnosis
  • Renal Insufficiency, Chronic / epidemiology*
  • Renal Insufficiency, Chronic / physiopathology
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Treatment Outcome