Ascorbic acid, cognitive function, and Alzheimer's disease: a current review and future direction

Biofactors. 2012 Mar-Apr;38(2):114-22. doi: 10.1002/biof.1002. Epub 2012 Mar 15.


This narrative review appraises the human and animal studies implicating ascorbic acid (AA) in normal cognitive function and Alzheimer's disease. A research framework for how nutrition affects brain aging is proposed with emphasis on AA intake, status, metabolism, and transport into brain tissue. A final synopsis highlights areas for future research regarding AA nourishment and healthy brain aging.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Animals
  • Ascorbic Acid / metabolism*
  • Brain / metabolism
  • Brain / physiopathology
  • Cognition / physiology*
  • Humans


  • Ascorbic Acid