[Effect of sodium succinate on oxidative stress in erythrocytes during physical loading]

Fiziol Zh (1994). 2011;57(6):71-9.
[Article in Ukrainian]


On the basis of model experiments in vitro with application of sodium succinate which is the basic constituent of dietary supplementation "YantarIn-Sport", possibility of correction of the structurally-functional state of red blood cell membranes is well-proven. It is show that prooxidative-antioxidative balance in washed erythrocytes is normalized with the accumulation of recovered glutathione from 2.34 to 3.12 x 10(-12) mM in one erythrocyte, and their sorption ability (from 35.6 to 27.1% as well as red blood cells permeability (from 4.61 to 3.98 conditional units) are decreased. In vivo research the positive influence of sodium succinate on descriptions of red blood cells of skilled sportsmen is confirmed, that is founding for application of succinic acid derivatives with the purpose of sporting anaemia' warning as well as improvement of microcirculation processes and increase of speed blood flow.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Cell Size / drug effects
  • Cells, Cultured
  • Citric Acid Cycle / drug effects
  • Dietary Supplements
  • Energy Metabolism / drug effects
  • Erythrocyte Membrane / drug effects
  • Erythrocyte Membrane / metabolism
  • Erythrocytes / drug effects*
  • Erythrocytes / metabolism
  • Glutathione / metabolism
  • Humans
  • Male
  • Oxidative Stress / drug effects*
  • Physical Exertion / drug effects*
  • Physical Exertion / physiology
  • Sports / physiology*
  • Succinates / administration & dosage
  • Succinates / pharmacology*
  • Young Adult


  • Succinates
  • Glutathione