Efficacy of subgingivally delivered simvastatin in the treatment of patients with type 2 diabetes and chronic periodontitis: a randomized double-masked controlled clinical trial

J Periodontol. 2013 Jan;84(1):24-31. doi: 10.1902/jop.2012.110721. Epub 2012 Mar 16.


Background: Simvastatin (SMV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Recently, it has been reported that statins promote bone formation. The present study is designed to investigate the effectiveness of 1.2% SMV in an indigenously prepared, biodegradable, controlled-release gel as an adjunct to scaling and root planing (SRP) in the treatment of patients with type 2 diabetes and chronic periodontitis (CP).

Methods: Thirty-eight patients were categorized into two treatment groups: SRP plus 1.2% SMV and SRP plus placebo. Clinical parameters were recorded at baseline before SRP and at 3, 6, and 9 months; they included modified sulcus bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL). At baseline and after 6 and 9 months, radiologic assessment of intrabony defect (IBD) fill was done using computer-aided software.

Results: Mean PD reduction and mean CAL gain were found to be greater in the SMV group than the placebo group at 3, 6, and 9 months. Furthermore, significantly greater mean percentage of bone fill was found in the SMV group (32.64% ± 12.90%) compared to the placebo group (4.22% ± 9.75%) after 9 months.

Conclusion: There was a greater decrease in mSBI and PD and more CAL gain with significant IBD fill at sites treated with SRP plus locally delivered SMV in patients with type 2 diabetes and CP.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alveolar Bone Loss / classification
  • Alveolar Bone Loss / drug therapy
  • Chronic Periodontitis / complications
  • Chronic Periodontitis / drug therapy*
  • Delayed-Action Preparations
  • Dental Scaling / methods
  • Diabetes Mellitus, Type 2 / complications*
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
  • Image Processing, Computer-Assisted / methods
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Osteogenesis / drug effects
  • Periodontal Attachment Loss / classification
  • Periodontal Attachment Loss / drug therapy
  • Periodontal Index
  • Periodontal Pocket / classification
  • Periodontal Pocket / drug therapy
  • Placebos
  • Root Planing / methods
  • Simvastatin / administration & dosage*
  • Treatment Outcome


  • Delayed-Action Preparations
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Placebos
  • Simvastatin