Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung

Lung Cancer. 2012 Jun;76(3):493-5. doi: 10.1016/j.lungcan.2012.02.014. Epub 2012 Mar 13.


In contrast to leukocytosis, paraneoplastic hypereosinophilia is uncommon in lung cancer. We present a patient with large-cell carcinoma of the lung, in which cancer cells generate large amounts of GM-CSF leading to a leukemoid reaction with prominent hypereosinophilia and potentially involved in autocrine tumor stimulation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Large Cell / complications*
  • Carcinoma, Large Cell / drug therapy
  • Carcinoma, Large Cell / metabolism*
  • Eosinophilia / diagnosis
  • Eosinophilia / etiology*
  • Fatal Outcome
  • Granulocyte Colony-Stimulating Factor / blood*
  • Humans
  • Lung Neoplasms / complications*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / metabolism*
  • Male
  • Middle Aged


  • Granulocyte Colony-Stimulating Factor