GEFs on the RhoAd to a colossal nucleus

Ramesh A Shivdasani

doi:10.1016/j.devcel.2012.02.010

GEFs on the RhoAd to a colossal nucleus

Dev Cell. 2012 Mar 13;22(3):471-2. doi: 10.1016/j.devcel.2012.02.010.

Author

Ramesh A Shivdasani¹

Affiliation

¹ Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA. ramesh_shivdasani@dfci.harvard.edu

PMID: 22421037
DOI: 10.1016/j.devcel.2012.02.010

Abstract

Cytokinesis in normal cell division requires RhoA-regulated actomyosin contraction of the cleavage furrow; this process is aborted in megakaryocyte endomitosis, leading to polyploidy. In this issue of Developmental Cell, Gao et al. (2012) trace the basis of endomitosis to sequential downregulation of guanine nucleotide exchange factors GEF-H1 and ECT2.

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