Polymeric multilayer capsules are emerging carrier systems in the field of drug delivery. These materials are fabricated by set-wise assembly of interaction species onto a sacrificial template followed by the decomposition of this template, yielding hollow capsules. Using bio-responsive polymers that can be triggered by pH, enzymes or reduction, several groups are exploring these systems for intracellular drug delivery. In this review we focus on the recent efforts made in investigating the in vitro and in vivo interaction between these capsules and cells of the immune system.
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