Leukoencephalopathies in adulthood

Semin Neurol. 2012 Feb;32(1):85-94. doi: 10.1055/s-0032-1306391. Epub 2012 Mar 15.

Abstract

The understanding of the genetic basis of late-onset leukoencephalopathies has continued to increase in recent years. The most commonly presenting leukoencephalopathies in adulthood can be late-onset manifestations of metabolic pathways. The understanding of these diagnoses is crucial to the evaluation of adult patients presenting with leukoencephalopathies. The authors provide an overview of the common leukoencephalopathies in adulthood, the current understanding of the pathology, and genetics of these disorders with typical imaging findings. When available, treatment options will be discussed.

Publication types

  • Review

MeSH terms

  • Adult
  • Age of Onset
  • Central Nervous System / metabolism
  • Central Nervous System / pathology
  • Hereditary Central Nervous System Demyelinating Diseases / diagnosis*
  • Hereditary Central Nervous System Demyelinating Diseases / epidemiology
  • Hereditary Central Nervous System Demyelinating Diseases / genetics*
  • Hereditary Central Nervous System Demyelinating Diseases / pathology
  • Humans
  • Leukoencephalopathies / diagnosis*
  • Leukoencephalopathies / epidemiology
  • Leukoencephalopathies / genetics*
  • Leukoencephalopathies / pathology