Comment on "Widespread RNA and DNA sequence differences in the human transcriptome"

Science. 2012 Mar 16;335(6074):1302; author reply 1302. doi: 10.1126/science.1210419.

Abstract

Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • DNA / genetics*
  • Genetic Variation*
  • Genome, Human*
  • Humans
  • RNA, Messenger / genetics*

Substances

  • RNA, Messenger
  • DNA