Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

Clin Infect Dis. 2012 Jun;54(12):1778-83. doi: 10.1093/cid/cis307. Epub 2012 Mar 15.

Abstract

We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Female
  • Humans
  • Immunosuppression
  • Incidence
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / adverse effects*
  • Male
  • Placebos / administration & dosage
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / immunology
  • Risk Assessment
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / adverse effects
  • Virus Diseases / epidemiology*
  • Virus Diseases / immunology

Substances

  • Influenza Vaccines
  • Placebos
  • Vaccines, Inactivated