Abstract
A series of 20 optically pure 3,4-dihydro-5H-pyrido[1',2':1,2]imidazo[4,5-d][1,3]diazepin-5-ones which form a new family of azaheterocycle-fused [1,3]diazepines were synthesized in four steps with 17-66% overall yields. The key step consists of a selective C-acylation reaction of easily accessible 2-aminoimidazo[1,2-a]pyridine at C-3.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acylation
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Benzodiazepines / chemical synthesis*
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Benzodiazepines / chemistry*
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Heterocyclic Compounds / chemistry*
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Imidazoles / chemistry*
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Molecular Structure
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Pyridines / chemistry*
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Stereoisomerism
Substances
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2-aminoimidazo(1,2-a)pyridine
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Heterocyclic Compounds
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Imidazoles
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Pyridines
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Benzodiazepines