Antibody-based immunotherapy of cancer

Cell. 2012 Mar 16;148(6):1081-4. doi: 10.1016/j.cell.2012.02.034.


By targeting surface antigens expressed on tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. Recent successful antibody-based strategies have focused on enhancing antitumor immune responses by targeting immune cells, irrespective of tumor antigens. We discuss these innovative strategies and propose how they will impact the future of antibody-based cancer therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / therapeutic use*
  • Cancer Vaccines / immunology
  • Cancer Vaccines / therapeutic use*
  • Humans
  • Immunotherapy
  • Neoplasms / immunology*
  • Neoplasms / therapy*


  • Antibodies, Monoclonal
  • Cancer Vaccines