The Amyloid State of Proteins in Human Diseases

Cell. 2012 Mar 16;148(6):1188-203. doi: 10.1016/j.cell.2012.02.022.

Abstract

Amyloid fibers and oligomers are associated with a great variety of human diseases including Alzheimer's disease and the prion conditions. Here we attempt to connect recent discoveries on the molecular properties of proteins in the amyloid state with observations about pathological tissues and disease states. We summarize studies of structure and nucleation of amyloid and relate these to observations on amyloid polymorphism, prion strains, coaggregation of pathogenic proteins in tissues, and mechanisms of toxicity and transmissibility. Molecular studies have also led to numerous strategies for biological and chemical interventions against amyloid diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid beta-Protein Precursor / chemistry*
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Disease Models, Animal
  • Humans
  • Models, Molecular
  • Neurodegenerative Diseases / metabolism*
  • Plaque, Amyloid / chemistry*
  • Protein Structure, Secondary

Substances

  • APP protein, human
  • Amyloid beta-Protein Precursor