New paradigms in translational science research in cancer biomarkers

Transl Res. 2012 Apr;159(4):343-53. doi: 10.1016/j.trsl.2012.01.015. Epub 2012 Feb 3.


Despite significant investments in basic science by the US National Institutes of Health, there is a concern that the return on this investment has been limited in terms of clinical utility. In the field of biomarkers, translational research is used to bridge the gap between the results of basic research that identify biomolecules involved in or the consequence of carcinogenesis and their incorporation into medical application. The cultural separation between different scientific disciplines often makes it difficult to establish the multidisciplinary and multi-skilled teams that are necessary for successful translational research. The field of biomarker research requires extensive interactions between academic researchers and industrial developers, and clinicians are needed to help shape the research direction that can be addressed only by a multidisciplinary, multi-institutional approach. In this article, we provide our perspective on the relatively slow pace of cancer biomarker translation, especially those for early detection and screening.

Publication types

  • Review

MeSH terms

  • Biomarkers / metabolism*
  • Biomarkers, Tumor / metabolism*
  • Humans
  • Neoplasms / diagnosis*
  • Neoplasms / metabolism*
  • Translational Medical Research / trends*


  • Biomarkers
  • Biomarkers, Tumor