p62: a versatile multitasker takes on cancer

Trends Biochem Sci. 2012 Jun;37(6):230-6. doi: 10.1016/j.tibs.2012.02.008. Epub 2012 Mar 15.

Abstract

Since its initial discovery as an atypical protein kinase C (PKC)-interacting protein, p62 has emerged as a crucial molecule in a myriad of cellular functions. This multifunctional role of p62 is explained by its ability to interact with several key components of various signaling mechanisms. Not surprisingly, p62 is required for tumor transformation owing to its roles as a key molecule in nutrient sensing, as a regulator and substrate of autophagy, as an inducer of oxidative detoxifying proteins, and as a modulator of mitotic transit and genomic stability; all crucial events in the control of cell growth and cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Adipogenesis
  • Autophagy
  • Cell Proliferation
  • Cell Survival
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • Genomic Instability
  • Humans
  • Mechanistic Target of Rapamycin Complex 1
  • Mitosis
  • Multiprotein Complexes
  • NF-kappa B / genetics
  • NF-kappa B / metabolism
  • Oxidative Stress
  • Proteins / genetics
  • Proteins / metabolism
  • Reactive Oxygen Species
  • Sequestosome-1 Protein
  • Signal Transduction*
  • TNF Receptor-Associated Factor 6 / genetics
  • TNF Receptor-Associated Factor 6 / metabolism
  • TOR Serine-Threonine Kinases

Substances

  • Adaptor Proteins, Signal Transducing
  • Multiprotein Complexes
  • NF-kappa B
  • Proteins
  • Reactive Oxygen Species
  • SQSTM1 protein, human
  • Sequestosome-1 Protein
  • TNF Receptor-Associated Factor 6
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1