Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients

Diabetes Res Clin Pract. 2012 May;96(2):e47-9. doi: 10.1016/j.diabres.2012.01.029. Epub 2012 Mar 15.


We investigated two single nucleotide polymorphisms of the NOS3 gene in type 2 diabetic patients (n=93) and healthy non-diabetic controls (n=76) and their relationship with smoking habits, body mass index, hypertension and dyslipidemia. Results showed that eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p<0.05).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Mass Index
  • Chile
  • Diabetes Mellitus, Type 2 / enzymology
  • Diabetes Mellitus, Type 2 / genetics*
  • Humans
  • Hypertension / enzymology*
  • Hypertension / genetics
  • Nitric Oxide Synthase Type III / genetics
  • Nitric Oxide Synthase Type III / metabolism*
  • Polymorphism, Single Nucleotide / genetics*
  • Smoking


  • NOS3 protein, human
  • Nitric Oxide Synthase Type III