Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress

Eur J Nutr. 2013 Feb;52(1):337-45. doi: 10.1007/s00394-012-0340-6. Epub 2012 Mar 18.

Abstract

Purpose: To examine the association of red meat and whole-grain bread consumption with plasma levels of biomarkers related to glucose metabolism, oxidative stress, inflammation and obesity.

Methods: Our cross-sectional study was based on 2,198 men and women who were selected as a sub-cohort for an investigation of biological predictors of diabetes and cardiovascular diseases from the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Circulating levels of glycated hemoglobin, adiponectin, hs-CRP, gamma-glutamyltransferase, alanine-aminotransferase, fetuin-A, HDL-cholesterol and triglycerides were measured from random blood samples. Diet and lifestyle data were assessed by questionnaires, and anthropometric data were measured.

Results: After multivariable adjustment, higher consumption of whole-grain bread was significantly (P trend <0.05) associated with lower levels of GGT, ALT and hs-CRP, whereas higher consumption of red meat was significantly associated with higher levels of GGT and hs-CRP when adjusted for potential confounding factors related to lifestyle and diet. Further adjustment for body mass index and waist circumference attenuated the association between red meat and hs-CRP (P = 0.19).

Conclusions: The results of this study suggest that high consumption of whole-grain bread is related to lower levels of GGT, ALT and hs-CRP, whereas high consumption of red meat is associated with higher circulating levels of GGT and hs-CRP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood
  • Alanine Transaminase / blood
  • Animals
  • Biomarkers / blood*
  • Blood Glucose / metabolism*
  • Body Mass Index
  • Bread*
  • C-Reactive Protein / analysis
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / metabolism
  • Cattle
  • Cholesterol, HDL / blood
  • Cross-Sectional Studies
  • Diet
  • Edible Grain
  • Female
  • Glycated Hemoglobin A / analysis
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Inflammation / blood*
  • Inflammation / metabolism
  • Life Style
  • Male
  • Meat*
  • Middle Aged
  • Obesity / blood*
  • Obesity / metabolism
  • Oxidative Stress*
  • Prospective Studies
  • Surveys and Questionnaires
  • Triglycerides / blood
  • Waist Circumference
  • alpha-2-HS-Glycoprotein / analysis
  • alpha-2-HS-Glycoprotein / metabolism
  • gamma-Glutamyltransferase / blood

Substances

  • Adiponectin
  • Biomarkers
  • Blood Glucose
  • Cholesterol, HDL
  • Glycated Hemoglobin A
  • Triglycerides
  • alpha-2-HS-Glycoprotein
  • C-Reactive Protein
  • gamma-Glutamyltransferase
  • Alanine Transaminase