A developmental and genetic classification for malformations of cortical development: update 2012

Brain. 2012 May;135(Pt 5):1348-69. doi: 10.1093/brain/aws019. Epub 2012 Mar 16.


Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain development and its perturbations. The rapid recent evolution of molecular biology, genetics and imaging has resulted in an explosive increase in our knowledge of cerebral cortex development and in the number and types of malformations of cortical development that have been reported. These advances continue to modify our perception of these malformations. This review addresses recent changes in our perception of these disorders and proposes a modified classification based upon updates in our knowledge of cerebral cortical development.

Publication types

  • Historical Article
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Movement / physiology
  • Cerebral Cortex* / abnormalities
  • Cerebral Cortex* / growth & development
  • Cerebral Cortex* / pathology
  • Developmental Disabilities / etiology
  • Diagnostic Imaging
  • Epilepsy / etiology
  • History, 21st Century
  • Humans
  • Malformations of Cortical Development* / classification
  • Malformations of Cortical Development* / complications
  • Malformations of Cortical Development* / genetics
  • Molecular Biology
  • Mutation / genetics*