Effects of dopamine on sensitivity to social bias in Parkinson's disease

PLoS One. 2012;7(3):e32889. doi: 10.1371/journal.pone.0032889. Epub 2012 Mar 9.


Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group differences were detected, but patients on medication were less biased by emotions than patients off medication and the strongest effects were seen in patients with ICBs. PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Analysis of Variance
  • Compulsive Behavior / chemically induced*
  • Compulsive Behavior / psychology*
  • Decision Making / drug effects
  • Dopamine / adverse effects*
  • Dopamine / therapeutic use
  • Emotions / drug effects*
  • Face
  • Female
  • Humans
  • London
  • Male
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / psychology
  • Photic Stimulation
  • Recognition, Psychology / drug effects


  • Dopamine