[High-dosage oral magnesium therapy in arrhythmias. Results of an observational study in 1.160 patients with arrhythmia]

Fortschr Med. 1990 Sep 30;108(28):539-42.
[Article in German]


In the treatment of cardiac arrhythmias of varying genesis, an "observational study" in 1,160 patients showed that a high-dose oral magnesium preparation (Magnesium-Diasporal N 300 Granulat) was effective. In 82% of the patients observed, a dose of at least 300 mg magnesium/day produced good to very good results. Adverse effects of the drug were observed in only 1.6% of the patients. For all groups, the "success parameters" improved significantly. High-rate arrhythmias showed a better response to magnesium treatment than did low-rate arrhythmias, with a close correlation being found with the heart rate at the start of treatment. High-dose oral magnesium had a positive effect on concomitant hypertension. At a dosage of 300 mg treatment should be continued for at least 6 weeks.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Arrhythmias, Cardiac / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Heart Rate / drug effects
  • Humans
  • Levulinic Acids / administration & dosage
  • Levulinic Acids / adverse effects
  • Levulinic Acids / therapeutic use*
  • Male
  • Middle Aged


  • Levulinic Acids
  • levulinic acid