Relationship Between Depression, Clinical and Biochemical Parameters in Patients Undergoing Haemodialysis

J Ren Care. 2012 Jun;38(2):93-7. doi: 10.1111/j.1755-6686.2012.00259.x. Epub 2012 Mar 17.

Abstract

In this paper, we investigated the incidence of depression and its relation to clinical, laboratory parameters and sleep disorders in 45 haemodialysis (HD) patients. They were divided into two groups. Group A (n = 29) had no depression, whereas Group B (n = 16) had clinically assessed depression. Subjects were compared in terms of socioeconomic, clinical, laboratory parameters and presence of sleep disorders. Groups were matched for age, sex, family status, education, self-esteem, coffee and alcohol consumption, psychiatric history, time on HD and laboratory (serum urea, creatinine, electrolytes, iron, albumin and lipids) parameters. Group B demonstrated significantly lower haemoglobin levels (11.13 ± 1.69 and 12.23 ± 1.31 g/dl, respectively; p < 0.01) and higher C-Reactive Protein (CRP) levels (1.82 ± 1.73 and 0.83 ± 0.6 mg/dl, respectively; p < 0.005) compared to Group A. Additionally, strong correlation was observed when Hamilton Depression Scale scores were related to haemoglobin (r =-0.30, p < 0.05), CRP (r = 0.38, p < 0.001) and AIS scores (r = 0.54, p < 0.0001). In conclusion, depression seems to be related to high CRP, low haemoglobin levels and sleep disorders.

MeSH terms

  • Adult
  • Aged
  • C-Reactive Protein / metabolism*
  • Comorbidity
  • Cross-Sectional Studies
  • Depressive Disorder / epidemiology
  • Depressive Disorder / nursing*
  • Depressive Disorder / physiopathology*
  • Depressive Disorder / psychology
  • Female
  • Hemoglobinometry / nursing*
  • Humans
  • Kidney Failure, Chronic / epidemiology
  • Kidney Failure, Chronic / nursing*
  • Kidney Failure, Chronic / physiopathology*
  • Kidney Failure, Chronic / psychology
  • Kidney Function Tests / nursing*
  • Male
  • Middle Aged
  • Personality Inventory / statistics & numerical data
  • Psychometrics
  • Renal Dialysis / nursing*
  • Renal Dialysis / psychology
  • Risk Factors
  • Sleep Initiation and Maintenance Disorders / epidemiology
  • Sleep Initiation and Maintenance Disorders / nursing*
  • Sleep Initiation and Maintenance Disorders / physiopathology
  • Sleep Initiation and Maintenance Disorders / psychology
  • Statistics as Topic

Substances

  • C-Reactive Protein