Impact of a resistant dextrin on intestinal ecology: how altering the digestive ecosystem with NUTRIOSE®, a soluble fibre with prebiotic properties, may be beneficial for health

J Int Med Res. 2012;40(1):211-24. doi: 10.1177/147323001204000122.


Objectives: The prebiotic potential of NUTRIOSE®--a sugar-free, digestion-resistant dextrin--was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively.

Methods: In study 1, the effect on colonic bacteria of NUTRIOSE® 10, 15 or 20 g/day administered for 14 days was examined; in study 2, gut microbial changes in response to NUTRIOSE® 8 g/day for 14 days were monitored using real-time polymerase chain reaction analysis.

Results: NUTRIOSE® increased proliferation of Bacteroides and inhibited Clostridum perfringens in both studies, increased β-glucosidase activity (at 10 and 15 g/day) and decreased colonic pH (at 20 g/day). The increase in short-chain fatty acid production with NUTRIOSE® consumption was not statistically significant. There were no indications of gastrointestinal intolerance at any dose.

Conclusions: According to commonly accepted definitions, NUTRIOSE® is a prebiotic soluble fibre that provides a beneficial effect on colonic ecology while preserving digestive comfort.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Bacteroides / drug effects
  • Bacteroides / growth & development
  • Clostridium perfringens / drug effects
  • Colony Count, Microbial
  • Dextrins / administration & dosage
  • Dextrins / pharmacology*
  • Dietary Fiber*
  • Feces / microbiology
  • Female
  • Health*
  • Humans
  • Hydrogen-Ion Concentration / drug effects
  • Intestines / drug effects*
  • Intestines / microbiology*
  • Male
  • Middle Aged
  • Prebiotics*
  • Solubility / drug effects


  • Dextrins
  • Dietary Fiber
  • Prebiotics