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Randomized Controlled Trial
. 2012;40(1):211-24.
doi: 10.1177/147323001204000122.

Impact of a Resistant Dextrin on Intestinal Ecology: How Altering the Digestive Ecosystem With NUTRIOSE®, a Soluble Fibre With Prebiotic Properties, May Be Beneficial for Health

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Randomized Controlled Trial

Impact of a Resistant Dextrin on Intestinal Ecology: How Altering the Digestive Ecosystem With NUTRIOSE®, a Soluble Fibre With Prebiotic Properties, May Be Beneficial for Health

C Lefranc-Millot et al. J Int Med Res. .

Abstract

Objectives: The prebiotic potential of NUTRIOSE®--a sugar-free, digestion-resistant dextrin--was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively.

Methods: In study 1, the effect on colonic bacteria of NUTRIOSE® 10, 15 or 20 g/day administered for 14 days was examined; in study 2, gut microbial changes in response to NUTRIOSE® 8 g/day for 14 days were monitored using real-time polymerase chain reaction analysis.

Results: NUTRIOSE® increased proliferation of Bacteroides and inhibited Clostridum perfringens in both studies, increased β-glucosidase activity (at 10 and 15 g/day) and decreased colonic pH (at 20 g/day). The increase in short-chain fatty acid production with NUTRIOSE® consumption was not statistically significant. There were no indications of gastrointestinal intolerance at any dose.

Conclusions: According to commonly accepted definitions, NUTRIOSE® is a prebiotic soluble fibre that provides a beneficial effect on colonic ecology while preserving digestive comfort.

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