Yohimbine use for physical enhancement and its potential toxicity

J Diet Suppl. 2011 Dec;8(4):346-54. doi: 10.3109/19390211.2011.615806. Epub 2011 Oct 21.


Yohimbine is a naturally sourced pharmacological agent, which produces hyperadrenergic physiological effects. In excess doses, it may typically cause agitation, anxiety, hypertension, and tachycardia. There is no conclusive evidence for this drug to be of benefit in bodybuilding, exercise tolerance, physical performance, or desirable alterations of body mass. Although tolerated generally well in low doses, the potential for dose-dependent toxicity should be recognized.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenergic Agents / adverse effects
  • Adrenergic Agents / pharmacology*
  • Adult
  • Animals
  • Exercise
  • Female
  • Humans
  • Male
  • Physical Fitness*
  • Plant Extracts / adverse effects
  • Plant Extracts / pharmacology*
  • Weight Lifting
  • Weight Loss / drug effects
  • Yohimbine / adverse effects
  • Yohimbine / pharmacology*
  • Young Adult


  • Adrenergic Agents
  • Plant Extracts
  • Yohimbine