Diffuse large cell non-Hodgkin lymphoma with pituitary and bilateral adrenal involvement

Intern Med J. 2012 Mar;42(3):329-32. doi: 10.1111/j.1445-5994.2011.02691.x.

Abstract

We describe an elderly male patient who presented with fever of unknown origin and refractory hyponatraemia. Following (18) fluorine-fluorodeoxyglucose positron emission tomography/computed tomography scan and core adrenal biopsy, the diagnosis of diffuse large B-cell non-Hodgkin lymphoma with pituitary and bilateral adrenal involvement was confirmed. After chemotherapy, his symptoms resolved, and all the lesions shrank significantly.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Glands / diagnostic imaging
  • Adrenal Glands / pathology*
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects
  • Dexamethasone / administration & dosage
  • Dexamethasone / adverse effects
  • Doxorubicin / administration & dosage
  • Doxorubicin / adverse effects
  • Fatal Outcome
  • Fever of Unknown Origin / etiology
  • Humans
  • Hyponatremia / etiology
  • Hyponatremia / physiopathology
  • Lymphoma, Large B-Cell, Diffuse / complications
  • Lymphoma, Large B-Cell, Diffuse / diagnostic imaging
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Male
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects
  • Multimodal Imaging
  • Pituitary Gland / diagnostic imaging
  • Pituitary Gland / pathology*
  • Pituitary-Adrenal System / physiopathology
  • Positron-Emission Tomography
  • Prednisone / administration & dosage
  • Prednisone / adverse effects
  • Tomography, X-Ray Computed
  • Ultrasonography
  • Vincristine / administration & dosage
  • Vincristine / adverse effects

Substances

  • Vincristine
  • Dexamethasone
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone
  • Methotrexate

Supplementary concepts

  • CHOP protocol