Steady and pulsatile flow fields in an end-to-side arterial anastomosis model

J Vasc Surg. 1990 Dec;12(6):747-53. doi: 10.1067/mva.1990.24365.


We investigated the flow field within a rigid-walled in vitro model of an end-to-side 45 degree anastomosis in an attempt to identify possible hemodynamic factors that may contribute to the pathogenesis of distal anastomotic intimal hyperplasia. A high-resolution photochromic tracer technique was used to visualize the flow in orthogonal planes and to determine the axial wall shear stress profiles for both steady and pulsatile flows over a range of physiologically relevant conditions. The flow field showed qualitative similarities to those seen in curved vessel: rapidly moving fluid from the graft section affects the bed of the host vessel, that is, the wall opposite the anastomosis, eventually advancing down the host vessel in a spiraling motion. A small mobile separation zone was noted at the toe of the anastomosis. Comparison of wall shear stress profiles with previously reported preferential sites for the development of intimal hyperplasia supported a low wall shear stress and/or flow separation pathogenesis hypothesis. One notable exception was the bed of the host artery that appeared to be subjected to a complex hemodynamic environment.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arteriovenous Shunt, Surgical / methods*
  • Blood Flow Velocity
  • Humans
  • In Vitro Techniques
  • Methylmethacrylate
  • Methylmethacrylates
  • Models, Cardiovascular*
  • Models, Structural*
  • Pulsatile Flow*
  • Stress, Mechanical


  • Methylmethacrylates
  • Methylmethacrylate