Acquisition of "Start" and "Stop" response thresholds in peak-interval timing is differentially sensitive to protein synthesis inhibition in the dorsal and ventral striatum

Front Integr Neurosci. 2012 Mar 14;6:10. doi: 10.3389/fnint.2012.00010. eCollection 2012.


Time-based decision-making in peak-interval timing procedures involves the setting of response thresholds for the initiation ("Start") and termination ("Stop") of a response sequence that is centered on a target duration. Using intracerebral infusions of the protein synthesis inhibitor anisomycin, we report that the acquisition of the "Start" response depends on normal functioning (including protein synthesis) in the dorsal striatum (DS), but not the ventral striatum (VS). Conversely, disruption of the VS, but not the DS, impairs the acquisition of the "Stop" response. We hypothesize that the dorsal and ventral regions of the striatum function as a competitive neural network that encodes the temporal boundaries marking the beginning and end of a timed response sequence.

Keywords: cortico-striatal circuits; decision-making; dopamine-glutamate interactions; memory consolidation; protein synthesis inhibitors; reward prediction; timing and time perception.