[The influence of bisphenol A and of combined exposure to X-rays and bisphenol A to somatic cells of the bone marrow and liver of mice]

Rocz Panstw Zakl Hig. 2011;62(4):439-44.
[Article in Polish]

Abstract

The aim of study was to estimate the effects of bisphenol A (BPA) and combined exposure to X-rays and BPA to somatic cells of the bone marrow and liver of mice. Male mice Pzh: Sfis were irradiated with 0.05 Gy or treated with BPA (5 mg/kg mc, 10 mg/kg mc, 20 mg/kg mc) or exposed to a combination of both (0.05 Gy + 5 mg/kg BPA) for 8 weeks. Samples were taken at 24h, 1, 4 and 8 weeks after the end of exposure. Our study showed, that BPA can induce, measured by Comet assay, DNA damage in limphocytes of the bone marrow. The induction of DNA damage in somatic cells of the liver was not detected. After combined exposure to both agents a greater migration of DNA in cells of both organs than after the exposure to bisphenol A alone was observed. Probably the X-rays intensify the genotoxicity of BPA.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Benzhydryl Compounds
  • Bone Marrow / drug effects*
  • Bone Marrow / radiation effects*
  • DNA Damage
  • Liver / drug effects*
  • Liver / radiation effects*
  • Male
  • Mice
  • Mutagenicity Tests
  • Phenols / toxicity*
  • Radiation Injuries, Experimental

Substances

  • Benzhydryl Compounds
  • Phenols
  • bisphenol A