Facial extensive recurrent basal cell carcinoma: successful treatment with photodynamic therapy and imiquimod 5% cream

Int J Dermatol. 2012 Apr;51(4):451-4. doi: 10.1111/j.1365-4632.2011.05293.x.


Background: Management of facial extensive recurrent basal cell carcinoma can be a challenge for dermatologists. Although the preferred technique is usually Mohs surgery, sometimes the patient's condition or predicted aggressive surgery make other options advisable.

Methods: We describe a case of a giant recurrent basal cell carcinoma in the face of an old woman successfully treated by combined therapy with MAL-photodynamic therapy and topical 5%.

Results: The patient remains well and with no sign of the tumor, with very good cosmetic result two years after treatment.

Conclusions: Management of extensive facial basal cell carcinoma with combined therapies, as photodynamic therapy followed by topical imiquimod, can be an option for selected cases such as ours.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Aminolevulinic Acid / analogs & derivatives
  • Aminolevulinic Acid / therapeutic use
  • Aminoquinolines / therapeutic use*
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma, Basal Cell / drug therapy*
  • Carcinoma, Basal Cell / surgery
  • Facial Neoplasms / drug therapy*
  • Facial Neoplasms / surgery
  • Female
  • Humans
  • Imiquimod
  • Neoplasm Recurrence, Local / drug therapy*
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / surgery


  • Aminoquinolines
  • Antineoplastic Agents
  • Photosensitizing Agents
  • methyl 5-aminolevulinate
  • Aminolevulinic Acid
  • Imiquimod