Soluble interleukin 2 receptor and tissue polypeptide antigen serum concentrations in end-stage renal failure

Nephron. 1990;56(2):157-61. doi: 10.1159/000186125.


Serum concentrations of soluble interleukin 2 receptor (IL-2R) were measured in 65 hemodialysis patients and compared with serum levels of beta 2-microglobulin and tissue polypeptide antigen (TPA). Elevated IL-2R levels, found in 85% of examined patients, correlated with elevated TPA serum concentrations (p less than 0.05). Patients with high IL-2R levels were significantly younger (p less than 0.05) than patients with low levels. Primary renal disease and residual renal function had no significant influence on TPA or IL-2R serum concentrations. In 16 patients with carpal tunnel syndrome, increased serum concentrations of IL-2R (p less than 0.005) and TPA (p less than 0.001) were found. We conclude that a non-specific dialysis-induced activation of epithelial and lymphoid cells rather than a specific immune response could explain the concomitant elevation of IL-2R and TPA serum concentrations in hemodialyzed patients. Patients with pronounced cell turnover, reflected by elevated IL-2R and TPA levels, may show an increased susceptibility to dialysis-associated amyloidosis.

MeSH terms

  • Aged
  • Amyloidosis / etiology
  • Antigens / blood
  • Carpal Tunnel Syndrome / blood
  • Carpal Tunnel Syndrome / etiology
  • Carpal Tunnel Syndrome / immunology
  • Humans
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / immunology*
  • Kidney Failure, Chronic / therapy
  • Middle Aged
  • Peptides / blood*
  • Receptors, Interleukin-2 / blood*
  • Renal Dialysis / adverse effects
  • Solubility
  • Tissue Polypeptide Antigen
  • beta 2-Microglobulin / metabolism


  • Antigens
  • Peptides
  • Receptors, Interleukin-2
  • Tissue Polypeptide Antigen
  • beta 2-Microglobulin