High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress

Clin Sci (Lond). 2012 Sep;123(5):313-21. doi: 10.1042/CS20110600.

Abstract

Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and β-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Blood Glucose / metabolism
  • Dietary Fats*
  • Energy Metabolism
  • Exercise / physiology*
  • Humans
  • Hypertriglyceridemia / blood
  • Hypertriglyceridemia / prevention & control*
  • Insulin / blood
  • Intercellular Adhesion Molecule-1 / blood
  • Lipoproteins, VLDL / metabolism
  • Liver / metabolism
  • Male
  • Oxidative Stress / physiology*
  • Postprandial Period / physiology*
  • Running / physiology
  • Triglycerides / blood*
  • Vascular Cell Adhesion Molecule-1 / blood
  • Walking / physiology

Substances

  • Biomarkers
  • Blood Glucose
  • Dietary Fats
  • Insulin
  • Lipoproteins, VLDL
  • Triglycerides
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1