Abstract
The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
MeSH terms
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Aging / metabolism*
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Animals
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Caloric Restriction*
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Energy Metabolism / drug effects*
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Enzyme Activation
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Enzyme Activators / administration & dosage
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Enzyme Activators / pharmacokinetics
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Enzyme Activators / therapeutic use*
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Evidence-Based Medicine
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Fungal Proteins / metabolism
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Humans
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Phosphodiesterase Inhibitors / administration & dosage
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Phosphodiesterase Inhibitors / pharmacokinetics
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Phosphodiesterase Inhibitors / therapeutic use*
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Resveratrol
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Sirtuin 1 / metabolism
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Stilbenes / administration & dosage
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Stilbenes / pharmacokinetics
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Stilbenes / therapeutic use*
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Yeasts / drug effects*
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Yeasts / enzymology
Substances
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Enzyme Activators
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Fungal Proteins
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Phosphodiesterase Inhibitors
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Stilbenes
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SIRT1 protein, human
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Sirtuin 1
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Resveratrol