The journey of resveratrol from yeast to human

Aging (Albany NY). 2012 Mar;4(3):146-58. doi: 10.18632/aging.100445.

Abstract

The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.

Publication types

  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Caloric Restriction*
  • Energy Metabolism / drug effects*
  • Enzyme Activation
  • Enzyme Activators / administration & dosage
  • Enzyme Activators / pharmacokinetics
  • Enzyme Activators / therapeutic use*
  • Evidence-Based Medicine
  • Fungal Proteins / metabolism
  • Humans
  • Phosphodiesterase Inhibitors / administration & dosage
  • Phosphodiesterase Inhibitors / pharmacokinetics
  • Phosphodiesterase Inhibitors / therapeutic use*
  • Resveratrol
  • Sirtuin 1 / metabolism
  • Stilbenes / administration & dosage
  • Stilbenes / pharmacokinetics
  • Stilbenes / therapeutic use*
  • Yeasts / drug effects*
  • Yeasts / enzymology

Substances

  • Enzyme Activators
  • Fungal Proteins
  • Phosphodiesterase Inhibitors
  • Stilbenes
  • SIRT1 protein, human
  • Sirtuin 1
  • Resveratrol