We report three patients with chronic lymphocytic leukemia with unusual vesiculo-bullous skin eruptions on exposed areas which were more commonly noted in spring and summer. The lesions appeared to be due to insect bites and could be differentiated from other causes on the basis of histological, immunohistological and clinical features. There was no correlation between the occurrence of the skin eruptions, disease status and treatment modalities. Exaggerated cutaneous reaction to insect bites should be considered as a cause of vesiculo-bullous lesions in patients with chronic lymphocytic leukemia.