Histopathological and biochemical findings of congenital copper deficiency: are these similar to those of caprine arthritis-encephalitis?

J Vet Sci. 2012 Mar;13(1):107-9. doi: 10.4142/jvs.2012.13.1.107.


This study was done after identifying animals with a twisted carpal joint in goat herd. These included a kid goat walking on its articulus carpii and a newborn goat with a stiff leg. Necropsies of the diseased goats revealed swollen carpal joints that were twisted backwards. Arthritis was observed during microscopic examination of the carpal joints. Very low levels of eosinophil, leucocyte, and lymphocyte cell infiltration were found in the central nervous system and meninges. Serum copper levels were significantly decreased in most of the animals. All of these results led us to diagnose the animals with swayback disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Carpal Joints / metabolism
  • Carpal Joints / pathology*
  • Copper / blood
  • Copper / deficiency*
  • Copper / metabolism
  • Female
  • Goat Diseases / congenital*
  • Goat Diseases / metabolism
  • Goat Diseases / pathology
  • Goats
  • Joint Diseases / congenital
  • Joint Diseases / metabolism
  • Joint Diseases / pathology
  • Joint Diseases / veterinary*
  • Male
  • Pregnancy


  • Copper