Infections and inflammatory diseases as risk factors for venous thrombosis. A systematic review

Thromb Haemost. 2012 May;107(5):827-37. doi: 10.1160/TH11-09-0611. Epub 2012 Mar 22.


Inflammation and venous thrombosis are intertwined. Only in the recent 15 years clinical epidemiological studies have focussed on inflammatory or infectious diseases as risk factors for venous thrombosis. Although a few reviews and many case reports or studies on these topic has been written, a review reporting relative or absolute risks for venous thrombosis has not been published yet. We performed a systematic review using Medline, Pubmed and Embase and found 31 eligible articles. Inflammatory bowel disease, ANCA-associated vasculitis, infections in general and more specifically, human immunodeficiency virus, pneumonia and urinary tract infections are associated with an increased risk of venous thrombosis.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Blood Coagulation
  • Communicable Diseases / blood
  • Communicable Diseases / epidemiology*
  • Communicable Diseases / immunology
  • Humans
  • Inflammation / blood
  • Inflammation / epidemiology*
  • Inflammation / immunology
  • Inflammation Mediators / metabolism
  • Risk Assessment
  • Risk Factors
  • Venous Thrombosis / blood
  • Venous Thrombosis / epidemiology*
  • Venous Thrombosis / immunology


  • Inflammation Mediators